Why the study?
The effects of sample matrix on high-sensitivity cardiac troponin I concentrations and cutoffs in rapid myocardial infarction algorithms were largely unknown.
Does the use of plasma versus serum sample types cause patient misclassification in 0/1 hour hs-cTnI algorithms?
Comparison
EDTA plasma or lithium heparin plasma vs serum hs-cTnI
Design
Comparative laboratory validation study
Authors
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EDTA plasma may disrupt troponin complex integrity in assays; extends sample-type observations but leaves standardization needs open.
Does the use of plasma versus serum sample types cause patient misclassification in 0/1 hour hs-cTnI algorithms?
Using different sample types (plasma vs. serum) for hs-cTnI assays can lead to significant patient misclassification in 0/1 hour algorithms, reinforcing the need to use a single sample type.
Kavsak et al. (2020) studied this question.
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