March 29, 2008AJP Heart and Circulatory PhysiologyOpen Access

Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury

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Population

Murine model of focal ischemia-reperfusion injury, divided into five separate groups based on time points.

Design

Preclinical

Follow-up

14 days

Authors

NONavdeep OjhaThe Ohio State University Wexner Medical Center SRSashwati RoyMcGowan Institute for Regenerative Medicine JRJared RadtkePacific Northwest Diabetes Research Institute

Discussion

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Implication

Supports MRI for serial infarct assessment in murine I/R models; leaves open clinical translation of evolving injury detection.

Structured PICO

Population

Murine model of focal ischemia-reperfusion (I/R) injury, divided into five separate groups based on time points.

Intervention

High-resolution (11.7 T) cardiac magnetic resonance imaging (MRI) and histological evaluation at 1 h, day 1, day 3, day 7, and day 14 post-I/R.

Outcome

Structural and functional changes in the myocardium, including infarct volume, regional wall motion, and wall thickness.surrogate

High-resolution MRI correlates well with histological staining in a murine model of ischemia-reperfusion injury, demonstrating that early functional compromise precedes structural myocyte disappearance.

Cite This Study

Ojha et al. (2008) studied this question.

synapsesocial.com/papers/6a76460ffccf1eb1fb88003c https://doi.org/10.1152/ajpheart.01190.2007

View Full Paper

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Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider