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January 10, 2026Journal of Cardiovascular Development and DiseaseOpen Access

Time to Reperfusion Dictates Cardiac Function and Myocardial Strain in a 7-Tesla Magnetic Resonance Imaging Rat Model

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Why the study?

To evaluate cardiac function, myocardial deformation, and the impact of infarction-to-reperfusion time using a rat model imaged with preclinical 7-tesla magnetic resonance imaging.

Does the duration of infarction-to-reperfusion time impact cardiac function and myocardial strain in a rat model evaluated by 7T-MRI?

Population

Wistar rats assigned to control (n = 6), 20 min (n = 10), 30 min (n = 6), or 40 min infarction (n = 6)

Comparison

20 min vs 30 min vs 40 min infarction followed by reperfusion vs controls

Design

Preclinical animal model study

Key result

Myocardial radial strain decreased significantly from 40.6% in controls to 34.0% in 20 min infarction, indicating early myocardial changes due to ischemia.

Authors

MIMako ItoJUJunpei UedaSYSei Yasuda

Discussion

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Member takes

Overview

May enable early ischemia detection in rat models; leaves open clinical translation of 7T-MRI strain imaging.

Key Points

  • The aim is to evaluate how the duration of myocardial infarction before reperfusion affects cardiac function and myocardial deformation in a rat model.
  • Utilized a rat model of coronary artery reperfusion with 7T-MRI imaging.
  • Divided Wistar rats into control and infarction groups (20, 30, and 40 min).
  • Assessed cardiac function using end-diastolic volume, end-systolic volume, and left-ventricular ejection fraction.
  • Analyzed myocardial deformation using radial, circumferential, and longitudinal strain.
  • 30 and 40 min infarction groups showed significant reductions in cardiac function compared to controls.
  • Radial strain decreased significantly from control (40.6%) to 20 min infarction group (34.0%, p < 0.05).
  • No significant difference in longitudinal strain was found between 30 and 40 min infarction groups.
  • Radial strain detects early myocardial changes at 20 min, while longitudinal strain may indicate compensatory efforts in severe cases.

Structured PICO

Does the duration of infarction-to-reperfusion time impact cardiac function and myocardial strain in a rat model evaluated by 7T-MRI?

P
Population
Wistar rats (n=28 total: 6 control, 10 in 20 min infarction group, 6 in 30 min infarction group, 6 in 40 min infarction group)
I
Intervention
Coronary artery infarction for 20, 30, or 40 minutes followed by reperfusion, imaged with preclinical 7-tesla magnetic resonance imaging (7T-MRI)
C
Comparator
Control group without myocardial infarction
O
Outcome
Cardiac function (end-diastolic volume, end-systolic volume, and left-ventricular ejection fraction) and myocardial deformation (circumferential strain, radial strain, and longitudinal strain)surrogate

In a preclinical rat model, 7T-MRI demonstrates that radial strain can detect early myocardial changes after just 20 minutes of ischemia, providing insights into the impact of infarction duration on myocardial deformation.

Cite This Study

Ito et al. (2025) studied this question. Myocardial radial strain decreased significantly from 40.6% in controls to 34.0% in 20 min infarction, indicating early myocardial changes due to ischemia.

synapsesocial.com/papers/6963223291e05aa366cb8c60https://doi.org/10.3390/jcdd13010010
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