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February 1, 1994European Journal of Clinical Investigation

Markers of platelet activation in coronary heart disease patients

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Why the study?

Does transluminal angioplasty affect levels of activated platelets in patients with unstable angina?

Population

16 patients with unstable angina undergoing transluminal angioplasty

Comparison

Transluminal angioplasty vs Pre-angioplasty levels and control donors

Design

Cohort

Follow-up

48 hours

Authors

ANAlan T. NurdenUniversité Paris-SudLMLaurent MacchiCentre National de la Recherche ScientifiqueCBClaude BihourScripps Research Institute

Discussion

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Implication

Activated platelet monitoring may be warranted post-angioplasty in unstable angina; hypothesis-generating and should not yet change practice.

Structured PICO

Does transluminal angioplasty affect levels of activated platelets in patients with unstable angina?

P
Population
16 patients with unstable angina undergoing transluminal angioplasty
I
Intervention
Transluminal angioplasty (all patients received background heparin and aspirin)
C
Comparator
Pre-angioplasty levels and control donors
O
Outcome
Levels of activated platelets measured by flow cytometry using monoclonal antibodies (Bx-1, AP-2, VH10, PAC-1)surrogate

Transluminal angioplasty can induce significant platelet activation in some patients with unstable angina despite standard heparin and aspirin therapy, peaking at 24 to 48 hours.

Cite This Study

Nurden et al. (1994) studied this question.

synapsesocial.com/papers/6a764a9edd478a52beb1bf8ehttps://doi.org/10.1111/j.1365-2362.1994.tb02426.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Activation in Unstable Coronary Disease1986 · 1,150 citations
  2. 2Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.1989 · 249 citations
  3. 3Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets1990 · 149 citations
  4. 4Thrombin-induced platelet aggregates have a dynamic structure. Time-dependent redistribution of glycoprotein IIb-IIIa complexes and secreted adhesive proteins.1991 · 26 citations
  5. 5Platelet aggregation and interaction with the coagulation system1990 · 30 citations