Why the study?
Does hypercholesterolaemia affect coronary flow velocity reserve and aortic distensibility in hypertensive patients without coronary artery disease?
Does hypercholesterolaemia affect coronary flow velocity reserve and aortic distensibility in hypertensive patients without coronary artery disease?
In hypertensive patients without epicardial coronary artery disease, hypercholesterolemia is associated with impaired coronary microvascular function and increased aortic stiffness.
Hypercholesterolaemia may impair CFR and aortic distensibility in hypertensives without CAD; hypothesis-generating for causality and intervention trials.
The aim of the present study was to assess the relationship between coronary flow velocity reserve (CFR), aortic distensibility indices, and levels of plasma total cholesterol (TC) in arterial hypertension. We studied 39 consecutive hypertensive patients free of coronary artery disease. Eighteen of them had normal TC and 21 had 1(8) high TC. Coronary flow velocity reserve and aortic elastic moduli were measured during stress transoesophageal echocardiography. Reduced CFR (2.41 + or - 0.75 vs. 1.97 + or - 0.60, p < 0.05), increased aortic elastic modulus (in 10(3) mmHg) (0.56 + or - 0.41 vs. 0.77 + or - 0.29, p < 0.05) and Young's modulus (in 10(3) mmHg) (5.42 + or - 4.03 vs. 8.57 + or - 4.79, p < 0.05) were found in hypercholesterolaemia.
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Nemes et al. (2009) studied this question.
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