April 19, 2011European Journal of Heart Failure
MitraClip in End-Stage Heart Failure: A Realistic Alternative to Surgery?
Why the study?
Does the MitraClip procedure improve clinical outcomes and reduce mitral regurgitation in patients with end-stage heart failure and severely reduced LV function?
Population
50 patients with heart failure, LV ejection fraction ≤25%, and mitral regurgitation of at least grade 3+…
Design
Editorial
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
The MitraClip procedure is a feasible and potentially beneficial treatment option for reducing severe functional mitral regurgitation and improving symptoms in high-risk patients with end-stage heart failure and severely reduced LV function.
Structured PICO
Does the MitraClip procedure improve clinical outcomes and reduce mitral regurgitation in patients with end-stage heart failure and severely reduced LV function?
P
Population
50 patients with heart failure, LV ejection fraction ≤25%, and mitral regurgitation (MR) of at least grade 3+, all in NYHA functional class III or IV.
I
Intervention
MitraClip procedure (endovascular edge-to-edge mitral valve repair)
O
Outcome
Feasibility, short-term durability, and clinical outcomes (including acute procedural success, MR reduction, mortality, NYHA class, 6-minute walk distance, LV volumes, and NT-proBNP)
The MitraClip procedure is a feasible and potentially beneficial treatment option for reducing severe functional mitral regurgitation and improving symptoms in high-risk patients with end-stage heart failure and severely reduced LV function.
Limitations
- Retrospective design
- Small sample size
- Short follow-up duration
Cite This Study
Heuvel et al. (2011) studied this question.