A Regiospecific Synthesis of Carbosubstituted Heteroaromatic Derivatives via Pd-Catalyzed Cross Coupling

The Pd-catalyzed cross-coupling reaction of e i t h e r h e t e m a r y l z i n c derivatives w i t h unsaturated organic halides o r h e t e m a r y l halides w i t h org a n o m t a l l i c reagents m n t a i n i n g Zn o r A1 can produce cleanly and regiospec i f i c a l l y the correspondingcarbo-substitutedhetemaromatic conpounds'in high y i e l d s .h e cmss-coupling reaction of o r g a n o m t a l l i c reagents w i t h orgimic halides i n the presence o f Ni 2 3 o r Pd catalysts has e m r g e d as a v e r s a t i l e and useful synthetic t o o l t h a t can complemnt the Cubased m t h ~d o l o g y .~