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March 15, 1991Proceedings of the National Academy of SciencesOpen Access

The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins.

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Authors

EWE. WertheimerYale UniversitySSShlomo SassonUniversity of British ColumbiaECErol CerasiHebrew University of Jerusalem

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Implication

Randomized trial examines GLUT-1's role as a stress protein in various cell types, suggesting a novel function during stress.

Key Points

  • The aim is to investigate whether GLUT-1 operates as a glucose-regulated stress protein in different cellular environments.
  • L8 myocytes and NIH 3T3 fibroblasts subjected to glucose starvation or chemical stressors (A23187, 2-mercaptoethanol, tunicamycin)
  • mRNA levels of GLUT-1 and GRP-78 measured over time
  • Ex vivo muscle incubation assessed changes in protein levels and glucose uptake
  • GLUT-1 mRNA increased by 50-300% in response to stressors
  • Calcium ionophore A23187 and 2-mercaptoethanol raised GLUT-1 protein levels by 2-3 times
  • No change in GLUT-4 expression during the same stress conditions

Cite This Study

Wertheimer et al. (1991) studied this question.

synapsesocial.com/papers/6a766308d8eb58afc2bd2c29https://doi.org/10.1073/pnas.88.6.2525
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