Why the study?
Does insulin, glucose, and lipid availability regulate GLUT1 and GLUT4 content in rat cardiac muscle in vivo?
Population
Chronically cannulated fasting and fed rats
Comparison
Infusion for 24 h with insulin while plasma… vs Saline infusion (fasting) and a fed control group
Design
Preclinical
Follow-up
24 h
Authors
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Should not alter clinical glucose transport management; leaves open human cardiac GLUT1 regulation by insulin and substrates.
Does insulin, glucose, and lipid availability regulate GLUT1 and GLUT4 content in rat cardiac muscle in vivo?
Insulin preferentially upregulates GLUT1 in cardiac muscle in vivo, a response that is modulated by substrate supply (glucose and lipids).
Laybutt et al. (1997) studied this question.
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