October 1, 1993Biochemical JournalOpen Access

Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4

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Population

Rat cardiac and skeletal muscle

Comparison

Fasting (48 h) and insulin stimulation vs 5 h fasting (basal state)

Design

Preclinical

Authors

EKEdward W. KraegenGarvan Institute of Medical Research JSJudith A SowdenGarvan Institute of Medical Research MHMichael B. HalsteadGarvan Institute of Medical Research

Discussion

Member takes

Implication

Hypothesis-generating for GLUT4 as dominant insulin-stimulated transporter in rodent heart; leaves human fasting or therapeutic relevance open.

Structured PICO

Population

Rat cardiac and skeletal muscle

Intervention

Fasting (48 h) and insulin stimulation

Comparator

5 h fasting (basal state)

Outcome

In vivo glucose uptake and levels of glucose transporters GLUT1 and GLUT4surrogate

GLUT4 primarily mediates insulin-stimulated glucose uptake in muscle, while GLUT1 plays a key role in basal cardiac glucose uptake which is markedly reduced during prolonged fasting.

Cite This Study

Kraegen et al. (1993) studied this question.

synapsesocial.com/papers/6a79ff3f4c448619ca0df797 https://doi.org/10.1042/bj2950287

View Full Paper

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Implication

Hypothesis-generating for GLUT4 as dominant insulin-stimulated transporter in rodent heart; leaves human fasting or therapeutic relevance open.

Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider