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September 1, 2023European Heart Journal OpenOpen Access

Prognosis prediction in cardiac amyloidosis by cardiac magnetic resonance imaging: a systematic review with meta-analysis

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Why the study?

The diagnostic role of CMR in cardiac amyloidosis is established, but the prognostic role of right and left CMR tissue characterization and functional parameters was yet to be delineated.

Do cardiac magnetic resonance imaging parameters predict all-cause mortality in patients with cardiac amyloidosis?

Comparison

Various right and left CMR tissue characterization and functional parameters

Design

Systematic review and meta-analysis

Follow-up

Median 24 months (IQR 20-32)

Authors

PBPaolo BorettoHeart Failure & TransplantNPNeal PatelWinthrop-University HospitalKPKeval PatelEssex Cardiothoracic Centre

Discussion

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Implication

CMR parameters predict mortality in cardiac amyloidosis; supports risk stratification models but requires prospective validation.

Structured PICO

Do cardiac magnetic resonance imaging parameters predict all-cause mortality in patients with cardiac amyloidosis?

P
Population
19 studies pooling 2,199 patients with light chain amyloidosis or transthyretin amyloidosis cardiac amyloidosis, median age 59.7 years, 66% male.
I
Intervention
Cardiac magnetic resonance (CMR) imaging parameters assessing right and left ventricular tissue characterization and function (including extracellular volume, LGE, native T1, GLS, EF)
O
Outcome
All-cause mortalityhard clinical

Cardiac magnetic resonance parameters, particularly extracellular volume and late gadolinium enhancement, are strong predictors of mortality in patients with cardiac amyloidosis.

Cite This Study

Boretto et al. (2023) studied this question.

synapsesocial.com/papers/6a76641b1db26fb0a4bc4f22https://doi.org/10.1093/ehjopen/oead092
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic value of right ventricular systolic function in cardiac amyloidosis2016 · 109 citations
  2. 2Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement2017 · 739 citations
  3. 3The prognostic value of T1 mapping and late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with light chain amyloidosis2018 · 100 citations
  4. 4Role of cardiovascular magnetic resonance in suspected cardiac amyloidosis: late gadolinium enhancement pattern as mortality predictor2017 · 18 citations
  5. 5Diagnostic accuracy of cardiovascular magnetic resonance for patients with suspected cardiac amyloidosis: a systematic review and meta-analysis2016 · 161 citations