Key result
A typical late gadolinium enhancement pattern on cardiovascular magnetic resonance was associated with a significantly higher risk of all-cause mortality (HR 3.2) in patients with suspected cardiac amyloidosis.
Why the study?
Does a typical LGE pattern on CMR predict all-cause mortality in patients with suspected cardiac amyloidosis?
Population
42 patients referred for cardiovascular magnetic resonance for suspected cardiac amyloidosis at Niguarda…
Comparison
Presence of a typical amyloidosis late… vs Absence of a typical amyloidosis LGE pattern on…
Design
Cohort
Follow-up
median 37 months (IQR 10-50 months)
Authors
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Typical LGE pattern identifies higher-risk suspected CA patients; leaves open independent prognostic value and management implications pending prospective validation.
Cohort (n=42)
Single-blind (image analysis blinded to patient identity)
No
Does a typical LGE pattern on CMR predict all-cause mortality in patients with suspected cardiac amyloidosis?
Hazard Ratio: 3.2 (95% CI 1.5–6.4)
p-value: p=<0.01
A typical LGE pattern on CMR is a strong predictor of all-cause mortality in patients with suspected cardiac amyloidosis.
Baroni et al. (2017) conducted a cohort in Suspected cardiac amyloidosis (n=42). Typical late gadolinium enhancement (LGE) pattern vs. Atypical LGE pattern was evaluated on All-cause mortality (HR 3.2, 95% CI 1.5-6.4, p=<0.01). A typical late gadolinium enhancement pattern on cardiovascular magnetic resonance was associated with a significantly higher risk of all-cause mortality (HR 3.2) in patients with suspected cardiac amyloidosis.
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