What question did this study set out to answer?

This research aims to determine the relationship between exercise and cardiovascular disease risk in women with nonmetastatic breast cancer.

May 24, 2016Journal of Clinical OncologyOpen Access

Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer

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Why the study?

Does exercise reduce the risk of cardiovascular events in women with nonmetastatic breast cancer?

Key Points

This research aims to determine the relationship between exercise and cardiovascular disease risk in women with nonmetastatic breast cancer.
Prospective study with 2,973 women diagnosed with nonmetastatic breast cancer.
Participants completed questionnaires assessing leisure-time physical activity in MET-h/wk.
Follow-up duration averaged 8.6 years, with multivariable analysis evaluating cardiovascular events.
Higher physical activity levels resulted in decreased incidence of cardiovascular events (Ptrend < .001).
Adjusted hazard ratios: 2 to 10.9 MET-h/wk (HR 0.91, 95% CI 0.76 to 1.09), 11 to 24.5 MET-h/wk (HR 0.79, 95% CI 0.66 to 0.96), ≥ 24.5 MET-h/wk (HR 0.65, 95% CI 0.53 to 0.80).
Adhering to guidelines of ≥ 9 MET-h/wk correlated with a 23% reduction in cardiovascular events (P < .001).

Structured PICO

Does exercise reduce the risk of cardiovascular events in women with nonmetastatic breast cancer?

Population

2,973 women (mean age, 57 years) diagnosed with nonmetastatic breast cancer participating in two registry-based, regional cohort studies.

Intervention

Higher levels of leisure-time recreational physical activity (measured in MET-h/wk, e.g., ≥ 24.5 MET-h/wk or adherence to guidelines ≥ 9 MET-h/wk)

Comparator

Lower levels of physical activity (< 2 MET-h/wk or < 9 MET-h/wk)

Outcome

First occurrence of any of the following: new diagnosis of coronary artery disease, heart failure, valve abnormality, arrhythmia, stroke, or CVD death, occurring after study enrollmentcomposite

Exercise is associated with substantial, graded reductions in the incidence of cardiovascular events in women with nonmetastatic breast cancer.

Discussion

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Implication

Supports exercise in breast cancer survivors; hypothesis-generating and requires RCTs to confirm causality.

Cite This Study

Jones et al. (2016) studied this question.

synapsesocial.com/papers/6a766e82232067cbf2ec063d https://doi.org/10.1200/jco.2015.65.6603

Topics

Women and heart disease Coronary artery disease Valvular heart disease Heart failure HFrEF treatment

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Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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