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October 1, 1995Endocrinology

Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II.

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Population

Confluent monolayers of porcine vascular smooth muscle cells

Comparison

Addition of IGFBP-1, IGFBP-2, [Trp221]IGFBP-1… vs Control (no addition) or IGF-I/IGF-II alone

Design

Preclinical

Follow-up

4 days

Authors

AGA GockermanTPTracy PrevetteJJJohn I. Jones

Discussion

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Overview

Should not change clinical practice; leaves open IGFBP-2 modulation of vascular remodeling in vivo.

Structured PICO

P
Population
Confluent monolayers of porcine vascular smooth muscle cells
I
Intervention
Addition of IGFBP-1, IGFBP-2, [Trp221]IGFBP-1, or insulin
C
Comparator
Control (no addition) or IGF-I/IGF-II alone
O
Outcome
Number of cells migrating over a fixed distance in 4 days after woundingsurrogate

IGF-binding proteins modulate IGF-stimulated vascular smooth muscle cell migration, highlighting a potential mechanism in vascular remodeling.

Cite This Study

Gockerman et al. (1995) studied this question.

synapsesocial.com/papers/6a767e3107527c8c91c44734https://doi.org/10.1210/endo.136.10.7545099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular smooth muscle cells synthesize two forms of insulin‐like growth factor binding proteins which are regulated differently by the insulin‐like growth factors1993 · 89 citations
  2. 2Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation.1990 · 193 citations
  3. 3Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms.1993 · 296 citations
  4. 4Association of insulin receptor substrate-1 with integrins1994 · 365 citations
  5. 5THE SMOOTH MUSCLE CELL1971 · 1,573 citations