Population
Isolated Ringer-perfused rabbit hearts (n=6) and dog hearts in situ (n=2)
Design
Preclinical
Follow-up
up to 3 minutes
Authors
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High DMI retention supports its use as a flow tracer in animal cardiac models; leaves open translation to clinical regional plasma flow quantification.
Desmethylimipramine demonstrates near-ideal characteristics as a molecular microsphere for quantifying regional plasma flow in cardiac tissue.
Little et al. (1983) studied this question.
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