What question did this study set out to answer?

To evaluate how obesity and nonketotic diabetes interact to regulate basal lipolysis and dynamic fat mobilization.

November 1, 1969Diabetes

The Interaction of Diabetes and Obesity on the Regulation of Fat Mobilization in Man

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Authors

JBJohn D. BagdadeUniversity of Oregon DPDaniel PorteUniversity of California, San Diego EBEdwin L. BiermanGeneral / Preventive / Lipids

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Implication

Clinical study demonstrates altered basal lipolysis and delayed fatty acid clearance in obese diabetic men, indicating fat mobilization defects require both conditions.

Key Points

To evaluate how obesity and nonketotic diabetes interact to regulate basal lipolysis and dynamic fat mobilization.
Evaluated 49 obese and nonobese, nondiabetic and nonketotic mildly diabetic male subjects.
Measured plasma free fatty acid (FFA) and glycerol concentrations in the basal state and following oral glucose tolerance testing.
Elevated basal FFA and glycerol levels were present exclusively in diabetic subjects who were also obese; basal levels correlated with carbohydrate intolerance only in obese individuals and with weight only in diabetic individuals.
Glycerol concentrations decreased at similar rates across all groups post-glucose ingestion, but obese diabetic subjects exhibited a delayed decline in plasma FFA, reflecting impaired re-esterification.

Cite This Study

Bagdade et al. (1969) studied this question.

synapsesocial.com/papers/6a7681617918a36617295751 https://doi.org/10.2337/diab.18.11.759

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Implication

Clinical study demonstrates altered basal lipolysis and delayed fatty acid clearance in obese diabetic men, indicating fat mobilization defects require both conditions.

The Interaction of Diabetes and Obesity on the Regulation of Fat Mobilization in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

The Interaction of Diabetes and Obesity on the Regulation of Fat Mobilization in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

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