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August 30, 2018European Journal of Preventive Cardiology

Prognostic value of the heart rate profile during exercise in patients with atrial fibrillation

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Why the study?

Does the heart rate profile during exercise predict heart failure events in patients with atrial fibrillation compared to those with sinus rhythm?

Population

2231 patients who underwent a symptom-limited maximal cardiopulmonary exercise test, including 321 with…

Comparison

Assessment of heart rate profile during exercise vs Patients with sinus rhythm

Design

Cohort

Follow-up

median 1262 (interquartile range 974-2921) days

Authors

KAKazufumi AiharaGunma UniversityYKYuko KatoShimane UniversitySSShinya SuzukiElectrophysiology

Discussion

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Implication

Exercise heart rate profiles may aid risk stratification in AF; leaves open incremental prognostic value beyond standard measures.

Structured PICO

Does the heart rate profile during exercise predict heart failure events in patients with atrial fibrillation compared to those with sinus rhythm?

P
Population
2231 patients who underwent a symptom-limited maximal cardiopulmonary exercise test, including 321 with atrial fibrillation and 1910 with sinus rhythm.
I
Intervention
Assessment of heart rate profile during exercise (peak heart rate and chronotropic response)
C
Comparator
Patients with sinus rhythm
O
Outcome
Occurrence of heart failure events, defined as hospitalization for heart failure or heart failure-related deathhard clinical

The exercise heart rate profile, specifically peak heart rate and chronotropic response, is a significant predictor of future heart failure events in patients with both atrial fibrillation and sinus rhythm.

Cite This Study

Aihara et al. (2018) studied this question.

synapsesocial.com/papers/6a768cf7dc95071596cfef64https://doi.org/10.1177/2047487318797398

Topics

Atrial fibrillationHeart failureHFrEF treatmentPersistent AF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronotropic Incompetence, Beta-Blockers, and Functional Capacity in Advanced Congestive Heart Failure: Time to Pace?2007 · 80 citations
  2. 2Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality2003 · 1,988 citations
  3. 3Deceptive meaning of oxygen uptake measured at the anaerobic threshold in patients with systolic heart failure and atrial fibrillation2014 · 40 citations
  4. 4Prevalence and Prognosis of Patients With Atrial Fibrillation in Japan2008 · 92 citations
  5. 5Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: data from the HF-ACTION trial2013 · 79 citations