Why the study?
Do intravenous dobutamine and nitroglycerin improve hemodynamics and reduce mitral regurgitation in patients with severe heart failure?
Population
12 patients with severe congestive heart failure
Comparison
Intravenous administration of dobutamine and… vs Control conditions
Design
Other
Authors
Loading...
Dobutamine and nitroglycerin may reduce MR volume and increase forward stroke volume in severe HF with high baseline fraction; leaves open effects on outcomes and therapy selection.
Do intravenous dobutamine and nitroglycerin improve hemodynamics and reduce mitral regurgitation in patients with severe heart failure?
In severe heart failure, dynamic mitral regurgitation is a key determinant of the hemodynamic response to dobutamine and nitroglycerin, with benefits seen primarily in those with significant baseline regurgitation.
Keren et al. (1989) studied this question.