September 1, 1984Circulation

Diltiazem-induced blockade of sympathetically mediated constriction of normal and diseased coronary arteries: lack of epicardial coronary dilatory effect in humans.

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Why the study?

Does intravenous diltiazem prevent sympathetically mediated constriction of coronary arteries during handgrip exercise in patients with coronary disease?

Population

13 patients with coronary disease

Comparison

Intravenous infusion of diltiazem during… vs Handgrip exercise without diltiazem and…

Authors

KHKenneth F. HossackSt Andrew’s Hospital BBB G BrownWinnMed DSDouglas K. StewartGreat Ormond Street Hospital

Discussion

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Implication

Diltiazem may blunt exercise-induced coronary constriction in CAD; extends mechanistic insights on calcium-channel blockade but leaves open outcome benefits.

Structured PICO

Does intravenous diltiazem prevent sympathetically mediated constriction of coronary arteries during handgrip exercise in patients with coronary disease?

Population

13 patients with coronary disease

Intervention

Intravenous infusion of diltiazem (0.25 mg/kg bolus followed by 0.003 mg/kg/min) during sustained isometric handgrip exercise

Comparator

Handgrip exercise without diltiazem (control) and nitroglycerin

Outcome

Hemodynamic and electrocardiographic responses, and computer-assisted measurements of normal and diseased segments of epicardial coronary arteriessurrogate

Intravenous diltiazem prevents sympathetically mediated coronary constriction during exercise but lacks the direct epicardial coronary dilatory effect seen with nitroglycerin.

Cite This Study

Hossack et al. (1984) studied this question.

synapsesocial.com/papers/6a76915c232067cbf2ec1ce6 https://doi.org/10.1161/01.cir.70.3.465

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Implication

Diltiazem may blunt exercise-induced coronary constriction in CAD; extends mechanistic insights on calcium-channel blockade but leaves open outcome benefits.

Diltiazem-induced blockade of sympathetically mediated constriction of normal and diseased coronary arteries: lack of epicardial coronary dilatory effect in humans.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diltiazem-induced blockade of sympathetically mediated constriction of normal and diseased coronary arteries: lack of epicardial coronary dilatory effect in humans.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider