Why the study?
Does the combined use of thiazide-type diuretics and beta-blockers increase the risk of new-onset diabetes compared to newer antihypertensive regimens in patients with hypertension?
Population
Patients with hypertension from randomized control trials featuring stepped treatment, assessing…
Comparison
Treatment regimens combining thiazide-type… vs Alternative therapy regimens avoiding the…
Design
Meta-analysis
Follow-up
at least 1 year
Authors
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Questions routine thiazide-beta-blocker combinations in hypertension; confirms higher diabetes risk versus alternatives.
Does the combined use of thiazide-type diuretics and beta-blockers increase the risk of new-onset diabetes compared to newer antihypertensive regimens in patients with hypertension?
The routine combined use of a thiazide diuretic with a beta-blocker in the early management of hypertension increases the risk of new-onset diabetes and should be questioned, particularly in high-risk patients.
Mason et al. (2005) studied this question.
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