Why the study?
Does levosimendan reduce postoperative heart failure in patients undergoing heart valve or combined heart valve and coronary artery bypass grafting surgery?
Population
200 patients assigned to undergo heart valve or combined heart valve and coronary artery bypass grafting…
Comparison
Levosimendan administered as a 24-hr infusion. vs Placebo administered as a 24-hr infusion.
Design
RCT, randomized, placebo-controlled
Follow-up
6 months
Authors
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Reduces postoperative heart failure after valve surgery; supports levosimendan but cautions against routine use given hypotension risk and neutral mortality.
Does levosimendan reduce postoperative heart failure in patients undergoing heart valve or combined heart valve and coronary artery bypass grafting surgery?
Levosimendan infusion reduces the incidence of postoperative heart failure in patients undergoing valve or combined valve/CABG surgery, but increases the risk of hypotension requiring vasopressors without improving mortality.
Lahtinen et al. (2011) studied this question.
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