Why the study?
Little was known regarding the mechanisms mediating shifts among fatty acid, glucose, and ketone body oxidation in diabetes mellitus, prompting investigation into whether myocardial glucose utilization directly influences ketone body catabolism.
Population
Ventricular cardiac tissue from four murine models and patients with type 2 diabetes mellitus and heart failure
Comparison
Models of diabetes, glucose intolerance, or altered glucose utilization vs controls, and diabetic vs nondiabetic patients
Design
Preclinical animal and translational human transcriptomic study
Authors
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Increased glucose availability may shift substrate use in diabetic HF; leaves open clinical impact and need for outcome trials.
Increased glucose availability suppresses cardiac ketolytic capacity through multiple mechanisms, highlighting crosstalk between glucose and ketone body metabolism in the diabetic myocardium.
Brahma et al. (2020) studied this question.
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