Why the study?
Does administration with food or antacid alter the oral absorption of misoprostol compared to fasting conditions?
Population
n=12 subjects
Comparison
Misoprostol administered with antacid or a… vs Misoprostol administered under fasting conditions
Design
Other
Authors
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Co-administration with food or antacid may alter misoprostol absorption; extends PK data but leaves clinical relevance open.
Does administration with food or antacid alter the oral absorption of misoprostol compared to fasting conditions?
Administration of misoprostol with food significantly slows its absorption rate and lowers peak plasma concentrations, which could potentially decrease systemic side effects.
Karim et al. (1989) studied this question.
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