Why the study?
Does the degree of renal impairment affect the pharmacokinetics of misoprostol acid after a single oral dose of misoprostol in subjects with varying renal function?
Population
48 subjects with various degrees of renal function
Comparison
Single 400 microgram oral dose of misoprostol vs Comparison across four groups based on renal…
Design
Cohort
Authors
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May warrant misoprostol dose caution in ESRD; leaves open need for prospective validation before practice change.
Does the degree of renal impairment affect the pharmacokinetics of misoprostol acid after a single oral dose of misoprostol in subjects with varying renal function?
The dose of misoprostol may need to be reduced in ESRD patients on prolonged hemodialysis due to significantly increased systemic exposure to its active metabolite.
Foote et al. (1995) studied this question.
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