Why the study?
Does PBN reduce reperfusion-induced ventricular fibrillation in isolated rat hearts with transient regional ischemia?
Population
Isolated perfused rat hearts subjected to transient regional ischemia induced by coronary artery ligation
Comparison
PBN added to the perfusate at 5-1,000 microM/L… vs Control group
Design
Preclinical
Authors
Loading...
Reduces reperfusion VF in isolated rat hearts; leaves open translation to clinical antiarrhythmic strategies.
Does PBN reduce reperfusion-induced ventricular fibrillation in isolated rat hearts with transient regional ischemia?
The free radical spin trap agent PBN significantly reduces vulnerability to reperfusion-induced ventricular fibrillation in an isolated rat heart model.
Hearse et al. (1987) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: