Why the study?
Does alpha-phenyl N-tert-butylnitrone (PBN) reduce free radical release and improve functional recovery in isolated perfused rat hearts undergoing ischemia-reperfusion injury?
Population
Isolated perfused rat hearts
Comparison
Spin trap alpha-phenyl N-tert-butylnitrone… vs Pre-ischemic values and varying durations of…
Design
Preclinical
Follow-up
30 min of reperfusion
Authors
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PBN may protect rat hearts from brief ischemia; hypothesis-generating for spin-trap use in human reperfusion injury.
Does alpha-phenyl N-tert-butylnitrone (PBN) reduce free radical release and improve functional recovery in isolated perfused rat hearts undergoing ischemia-reperfusion injury?
The spin trap PBN reduces rhythm disturbances and improves recovery after short (20 min) ischemia in isolated rat hearts, but becomes toxic with longer ischemia durations.
Vergely et al. (2001) studied this question.
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