November 1, 1999Journal of Biological ChemistryOpen Access

Role of the Inositol 1,4,5-Trisphosphate Receptor in Ca2+ Feedback Inhibition of Calcium Release-activated Calcium Current (I crac)

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Population

RBL-1 cells

Design

Preclinical

Authors

LBLisa M. BroadEli Lilly (United States)DADavid L. ArmstrongTexas A&M University – Corpus Christi JPJames W. PutneyUniversity of Southern California

Discussion

Member takes

Implication

No immediate clinical implications; leaves open differential I(crac) activation by IP3 agonists in cardiovascular models.

Structured PICO

Population

RBL-1 cells

Intervention

Ca2+ store-depleting agents (ionomycin, thapsigargin, inositol 1,4,5-trisphosphate [IP3], adenophostin A, and GPIP2) under varying intracellular Ca2+ buffering conditions

Outcome

Activation of calcium release-activated calcium current (I(crac))surrogate

IP3 receptors on discrete IP3-sensitive Ca2+ pools play an important role in calcium feedback regulation of I(crac) and capacitative calcium entry.

Cite This Study

Broad et al. (1999) studied this question.

synapsesocial.com/papers/6a76dc2cd2fa2470761e7b85 https://doi.org/10.1074/jbc.274.46.32881

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Role of the Inositol 1,4,5-Trisphosphate Receptor in Ca2+ Feedback Inhibition of Calcium Release-activated Calcium Current (I crac)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of the Inositol 1,4,5-Trisphosphate Receptor in Ca2+ Feedback Inhibition of Calcium Release-activated Calcium Current (I crac)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider