Population
Rat diaphragm muscle fibres
Comparison
Denervation vs Normal muscle fibres
Design
Preclinical
Follow-up
A few weeks
Authors
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May guide timing of interventions after acute denervation; leaves open human translation and therapeutic targeting.
Denervation of skeletal muscle leads to early hypertrophy followed by late atrophy due to fragmentation and myofilament disintegration.
Miledi et al. (1969) studied this question.
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