Population
Ca(2+)-activated myofibrils
Comparison
Chemical cross-linking with… vs Un-cross-linked myofibrils (isotonic contraction)
Design
Preclinical
Authors
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Cross-linking halves myofibrillar ATPase in animal models; hypothesis-generating for isometric energetics in human myocardium.
Cross-linking myofibrils to prevent shortening reduces their ATPase activity, consistent with the observation that isometrically contracting fibers have lower ATPase activity than those shortening at moderate velocity.
Herrmann et al. (1993) studied this question.
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