Key result
Atenolol significantly increased peripheral augmentation index compared with metoprolol succinate (P < 0.05), though both had similar effects on blood pressure and endothelial function.
Why the study?
Does atenolol compared to metoprolol succinate affect vascular function in patients with hypertension?
RCT (n=24)
Double-blind
Randomized crossover
Does atenolol compared to metoprolol succinate affect vascular function in patients with hypertension?
p-value: p=< 0.05
Atenolol increases peripheral augmentation index compared to metoprolol succinate in hypertensive patients, suggesting differential effects on vascular function despite similar blood pressure reduction.
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May warrant preferring metoprolol over atenolol in hypertension; challenges beta-blocker class equivalence and extends vascular research.
Heffernan et al. (2011) conducted an RCT in essential hypertension (n=24). Atenolol vs. Metoprolol succinate was evaluated on Vascular function including peripheral augmentation index (AIx), pulse wave amplitude reactive hyperemia index, and brachial artery flow-mediated dilation (p=< 0.05). Atenolol significantly increased peripheral augmentation index compared with metoprolol succinate (P < 0.05), though both had similar effects on blood pressure and endothelial function.
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