Key result
Interventional techniques for resistant hypertension result in impressive office blood pressure falls but modest ambulatory reductions, a disparity potentially explained by sympathetic overactivity.
Why the study?
Should ambulatory blood pressure monitoring be mandatory for future studies evaluating interventional management of resistant hypertension?
Should ambulatory blood pressure monitoring be mandatory for future studies evaluating interventional management of resistant hypertension?
The authors propose that ambulatory blood pressure monitoring should be mandatory in future studies of resistant hypertension interventions to account for disparities between office and ambulatory blood pressure reductions.
Recent technologic advances rekindled interventional management of resistant hypertension, either by carotid baroreceptor activation or renal sympathetic denervation. Interventional techniques result in impressive falls in office blood pressure (BP); however, ambulatory BP reductions are rather modest. This disparity between office and ambulatory BP reductions is observed with antihypertensive drugs, but at a much lower degree. Available explanations are not convincing, therefore, we propose that sympathetic overactivity may partially explain this divergence. Further studies are needed to prove or disprove our hypothesis.
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Doumas et al. (2012) conducted an editorial in resistant hypertension. ambulatory blood pressure monitoring was evaluated. Interventional techniques for resistant hypertension result in impressive office blood pressure falls but modest ambulatory reductions, a disparity potentially explained by sympathetic overactivity.