Why the study?
Does acetylcholine or adrenaline alter pulmonary arterial pressure and venous outflow in isolated dog lungs?
Population
Isolated lung preparations of the dog under negative pressure ventilation and perfused with defibrinated blood
Design
Preclinical
Authors
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These isolated-lung findings should not change practice; leaves open dose-dependent cholinergic effects for future translational study.
Does acetylcholine or adrenaline alter pulmonary arterial pressure and venous outflow in isolated dog lungs?
Acetylcholine exhibits dose-dependent effects on pulmonary arterial pressure in isolated dog lungs, which are independent of bronchomotor mechanisms.
Alcock et al. (1935) studied this question.
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