Key result
In rats with renovascular hypertension, telmisartan combined with linagliptin normalized systolic blood pressure compared to placebo (100.4 vs 157.7 mmHg; P<0.001).
Why the study?
Does linagliptin alone or in combination with telmisartan improve blood pressure and oxidative stress in rats with renovascular hypertension?
RCT (n=69)
randomly divided
Does linagliptin alone or in combination with telmisartan improve blood pressure and oxidative stress in rats with renovascular hypertension?
Absolute Event Rate: 100.4% vs 157.7%
p-value: p=<0.001
In a rat model of renovascular hypertension, linagliptin reduced oxidative stress independently of blood pressure, while telmisartan normalized blood pressure and prevented cardiac hypertrophy.
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Hypothesis-generating for telmisartan-linagliptin in renovascular hypertension models; leaves open translation to human therapy.
Chaykovska et al. (2013) conducted an RCT in renovascular hypertension (n=69). Telmisartan and linagliptin combination vs. placebo was evaluated on systolic blood pressure (p=<0.001). In rats with renovascular hypertension, telmisartan combined with linagliptin normalized systolic blood pressure compared to placebo (100.4 vs 157.7 mmHg; P<0.001).
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