Why the study?
Does the combination of telmisartan and hydrochlorothiazide reduce blood pressure and alter renal excretory function compared to monotherapy or vehicle in spontaneously hypertensive rats?
Population
116 male spontaneously hypertensive rats
Comparison
Telmisartan 3 mg/kg + hydrochlorothiazide 10… vs Vehicle, telmisartan 3 mg/kg alone, and HCTZ 10…
Design
Preclinical
Follow-up
5 days
Authors
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Supports preclinical ARB/diuretic synergy testing in hypertension models; leaves open clinical translation pending human trials.
Does the combination of telmisartan and hydrochlorothiazide reduce blood pressure and alter renal excretory function compared to monotherapy or vehicle in spontaneously hypertensive rats?
Co-administration of telmisartan and hydrochlorothiazide augments antihypertensive efficacy in spontaneously hypertensive rats while promoting renal water and electrolyte excretion with possible attenuation of HCTZ-related potassium loss.
Wienen et al. (2001) studied this question.
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