What question did this study set out to answer?

To determine whether hyperinsulinemia correlates with cardiovascular risk factors and the incidence of acute myocardial infarction and stroke in Japanese men with borderline to mild hypertension.

January 1, 1996Hypertension ResearchOpen Access

Insulin and Cardiovascular Diseases in Japanese Work- Site Population with Borderline to Mild Hypertension

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Why the study?

Does hyperinsulinemia increase the risk of acute myocardial infarction and stroke in Japanese middle-aged men with borderline to mild hypertension?

Population

584 male employees of a Japanese railroad company with borderline to mild hypertension, mean age 49 +/- 7…

Comparison

Hyperinsulinemia vs Lower serum insulin levels

Design

Cohort

Follow-up

7 years

Authors

STShuichi TakishitaKagoshima University IAIsao AbeAjinomoto (United States)KKKazuo KobayashiYokohama City University Medical Center

Discussion

Member takes

Implication

Hyperinsulinemia was associated with higher MI but not stroke risk; leaves open independent predictive value and need for larger prospective confirmation.

Key Points

To determine whether hyperinsulinemia correlates with cardiovascular risk factors and the incidence of acute myocardial infarction and stroke in Japanese men with borderline to mild hypertension.
Evaluated 584 untreated male railroad company employees with borderline to mild hypertension (age 49 ± 7 years, BP 139/90 mmHg, BMI 24.0 ± 2.8) stratified into quintiles by post-load insulin response (sigma IRI).
Conducted multiple regression analyses across metabolic markers and registered incident acute myocardial infarction and stroke over a 7-year follow-up period.
Sigma IRI correlated positively with BMI, glucose area, systolic blood pressure, and total cholesterol, while associating negatively with HDL-cholesterol.
Over the 7-year follow-up, 7 cases of myocardial infarction and 15 cases of stroke occurred, with myocardial infarction cases clustered in higher insulin deciles whereas stroke cases were not.

Structured PICO

Does hyperinsulinemia increase the risk of acute myocardial infarction and stroke in Japanese middle-aged men with borderline to mild hypertension?

Population

584 male employees of a Japanese railroad company with borderline to mild hypertension, mean age 49 +/- 7 years. Excluded: those taking antihypertensive drugs and/or hypoglycemic agents, history of cardiovascular diseases except hypertension, and overt diabetes mellitus.

Intervention

Hyperinsulinemia (assessed by fasting serum insulin and area under the curve during 75g oral glucose tolerance test)

Comparator

Lower serum insulin levels (analyzed by quintiles/deciles)

Outcome

Incidence of first-ever acute myocardial infarction (MI) and first-ever strokehard clinical

Hyperinsulinemia is associated with an increased risk of coronary heart disease, but not cerebrovascular disease, in Japanese middle-aged men with borderline to mild hypertension.

Limitations

Small sample size
Limited population (only male railroad employees)
Subjects were regularly advised by health nurses and enrolled in prevention programs, which may underestimate the association between insulin and cardiovascular events

Cite This Study

Takishita et al. (1996) studied this question.

synapsesocial.com/papers/6a770a4ed8eb58afc2bd948d https://doi.org/10.1291/hypres.19.supplementi_s13

Topics

Hypertension management

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Implication

Hyperinsulinemia was associated with higher MI but not stroke risk; leaves open independent predictive value and need for larger prospective confirmation.

Insulin and Cardiovascular Diseases in Japanese Work- Site Population with Borderline to Mild Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Insulin and Cardiovascular Diseases in Japanese Work- Site Population with Borderline to Mild Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider