December 15, 2017European Journal of Preventive Cardiology
Cardiopulmonary exercise testing and risk stratification in heart failure with reduced, midrange or preserved ejection fraction: When nomenclature may not match with pathophysiology
Key result
Peak VO2 was a common independent predictor of adverse cardiac-related events across all three heart failure ejection fraction categories (HFrEF, HFmrEF, and HFpEF).
Why the study?
Do CPET-derived variables predict adverse cardiac-related events in heart failure patients across different LVEF categories?
Population
1190 heart failure patients categorized into HFrEF (41.9%), HFpEF (36.8%), and HFmrEF (21.3%)
Design
Editorial
Authors
Discussion
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Implication
Peak VO2 derived from CPET provides robust prognostic information across all heart failure phenotypes regardless of ejection fraction category.
Structured PICO
Do CPET-derived variables predict adverse cardiac-related events in heart failure patients across different LVEF categories?
P
Population
1,190 heart failure patients categorized by LVEF (HFrEF, HFmrEF, HFpEF) to evaluate the prognostic ability of CPET-derived variables.
E
Exposure
Cardiopulmonary exercise testing (CPET) derived variables (peak VO2, VE/VCO2 slope, OUES, EOV)
O
Outcome
Adverse cardiac-related eventshard clinical
Peak VO2 derived from CPET provides robust prognostic information across all heart failure phenotypes regardless of ejection fraction category.
Limitations
- Single center study
- Retrospective design
- Fails to focus on the reproducibility of echocardiographic LVEF measures
- Single center
- Fails to focus on reproducibility of LVEF measures obtained by echocardiography
Cite This Study
Marco Guazzi (2017) conducted an editorial in Heart failure (n=1,190). Cardiopulmonary exercise testing (CPET) variables was evaluated on Adverse cardiac-related events. Peak VO2 was a common independent predictor of adverse cardiac-related events across all three heart failure ejection fraction categories (HFrEF, HFmrEF, and HFpEF).