January 1, 2000Thrombosis and Haemostasis

Homocysteine and Oxidized Low Density Lipoprotein Enhance Platelet Adhesion to Endothelial Cells under Flow Conditions: Distinct Mechanisms of Thrombogenic Modulation

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Structured PICO

Population

human endothelial cells (EC) and platelets

Intervention

homocysteine (1 or 10 mmol/L for 16 h) or oxidized low density lipoprotein (ox-LDL) (100 µg/ml for 16 h)

Outcome

platelet adhesion to human endothelial cells (EC) under flow conditions at a shear rate of 350 s−1surrogate

Homocysteine and ox-LDL increase endothelial thrombogenicity through distinct mechanisms, with homocysteine inducing tissue factor activity and ox-LDL upregulating ICAM-1.

Discussion

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Implication

Hypothesis-generating for homocysteine- and ox-LDL-driven endothelial thrombogenicity; leaves open relevance to human disease.

Cite This Study

Varon et al. (2000) studied this question.

synapsesocial.com/papers/6a771551a0847c3df1ec52df https://doi.org/10.1055/s-0037-1613809

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Homocysteine and Oxidized Low Density Lipoprotein Enhance Platelet Adhesion to Endothelial Cells under Flow Conditions: Distinct Mechanisms of Thrombogenic Modulation

Structured PICO

Discussion

Implication

Cite This Study

Homocysteine and Oxidized Low Density Lipoprotein Enhance Platelet Adhesion to Endothelial Cells under Flow Conditions: Distinct Mechanisms of Thrombogenic Modulation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider