Key result
Homocysteine caused a concentration-dependent inhibition of l-arginine transport and decreased NO formation, while increasing intracellular Ca2+ concentration and platelet response to thrombin.
Homocysteine impairs the l-arginine/NO pathway and increases intracellular calcium in human platelets, potentially contributing to hyperactivation and thrombogenic processes.
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May promote platelet hyperreactivity in hyperhomocysteinemia; hypothesis-generating and should not yet change practice.
Leoncini et al. (2003) studied this question. Homocysteine was evaluated on l-arginine transport, NO formation, and Ca2+ levels. Homocysteine caused a concentration-dependent inhibition of l-arginine transport and decreased NO formation, while increasing intracellular Ca2+ concentration and platelet response to thrombin.
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