March 1, 1989Journal of VirologyOpen Access

Structural defect linked to nonrandom mutations in the matrix gene of biken strain subacute sclerosing panencephalitis virus defined by cDNA cloning and expression of chimeric genes

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Biken strain (a nonproductive measles viruslike agent isolated from a subacute sclerosing panencephalitis patient) and its cloned matrix (M) gene

Intervention

cDNA cloning and expression of chimeric M genes in vitro and in vivo

Comparator

Edmonston strain measles virus M protein

Outcome

Protein expression, stability, antigenicity, and conformation

The structural defect and instability of the Biken strain M protein are attributed to multiple mutations in both the amino and carboxy regions, sharing identical mutations with another independently isolated SSPE virus strain.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Biken M protein instability supports SSPE pathogenesis; extends shared mutation data across strains but leaves open mechanistic validation.

Cite This Study

Ayata et al. (1989) studied this question.

synapsesocial.com/papers/6a77224098f24dbf64bd6e02 https://doi.org/10.1128/jvi.63.3.1162-1173.1989

View Full Paper

Ask AI

Bookmark

Implication

Biken M protein instability supports SSPE pathogenesis; extends shared mutation data across strains but leaves open mechanistic validation.

Structural defect linked to nonrandom mutations in the matrix gene of biken strain subacute sclerosing panencephalitis virus defined by cDNA cloning and expression of chimeric genes

Structured PICO

Discussion

Implication

Cite This Study

Structural defect linked to nonrandom mutations in the matrix gene of biken strain subacute sclerosing panencephalitis virus defined by cDNA cloning and expression of chimeric genes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider