Key result
Isograft transplantation to supplement renal mass in 5/6 nephrectomized rats lowered systolic blood pressure by approximately 35 mmHg and attenuated glomerular hyperfiltration.
Why the study?
Does augmenting renal mass by isograft transplantation reduce blood pressure and progression of kidney disease in 5/6 nephrectomized rats?
Does augmenting renal mass by isograft transplantation reduce blood pressure and progression of kidney disease in 5/6 nephrectomized rats?
Answers are grounded in this paper and cite their sources.
Supplementing renal mass via isograft transplantation in 5/6 nephrectomized rats significantly lowers systolic blood pressure and attenuates glomerular injury, supporting renal mass as an independent determinant of arterial pressure.
BACKGROUND: To test the hypothesis that nephron mass is an independent determinant of arterial pressure, the effects of augmenting renal mass by isograft transplantation were studied in the model of secondary hypertension. METHODS: The effects of isograft transplantation or sham operation on blood pressure, proteinuria, remnant kidney mass, glomerular filtration rate and glomerulosclerosis were assessed in 5/6 nephrectomized (5/6 NPX) rats. RESULTS: Systolic blood pressure was lowered on average by approximately 35 mmHg and glomerular hyperfiltration was attenuated in the remnant kidneys of transplant recipients. Markedly lower urinary protein excretion rates and glomerulosclerosis scores in the remnant kidney accompanied these supplemental transplants to values roughly one-third of those from sham-operated rats. CONCLUSIONS: The data show that reduced renal mass per se is the major factor in the development and maintenance of arterial hypertension and glomerular injury in 5/6 NPX rats and these changes can be reversed by supplementing renal mass. The data provide strong support for the notion that renal mass is a significant, independent determinant of arterial pressure.
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Mai Ots (2004) studied Secondary hypertension. Isograft transplantation (supplementation of kidney mass) vs. Sham operation was evaluated on Blood pressure, proteinuria, remnant kidney mass, glomerular filtration rate and glomerulosclerosis (35 mmHg reduction). Isograft transplantation to supplement renal mass in 5/6 nephrectomized rats lowered systolic blood pressure by approximately 35 mmHg and attenuated glomerular hyperfiltration.
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