Key result
National reference standards for EV71 vaccines based on the C4 subtype showed good linearity and parallelism, and effectively reduced neutralizing antibody assay discrepancy between different labs.
Population
Mice immunized with various EV71 vaccines and laboratory assays for EV71 vaccines
Design
Preclinical
Authors
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May aid preclinical EV71 vaccine assay standardization; leaves open clinical translation and requires human validation.
The development of national reference standards for EV71 vaccines enables standardized quality control and evaluation of vaccine effectiveness.
Liang et al. (2011) studied Enterovirus 71 (EV71) infection / Hand-foot-mouth disease (HFMD). National reference standards for EV71 vaccines (antigen and NTAb) was evaluated on Linearity, parallelism, and assay discrepancy reduction. National reference standards for EV71 vaccines based on the C4 subtype showed good linearity and parallelism, and effectively reduced neutralizing antibody assay discrepancy between different labs.
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