Why the study?
Do estradiol and testosterone alter Fas-dependent apoptosis in CVB3-specific Th2 cells?
Population
Coxsackievirus B3 (CVB3)-specific Th1 and Th2 cell clones (derived from BALB/c mice)
Comparison
17beta estradiol and 4-androsten-17beta-ol-one… vs 0 ng/ml (untreated control)
Design
Preclinical
Follow-up
2 days
Authors
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May underlie sex differences in viral myocarditis; leaves open human translation of hormone effects on T-cell apoptosis.
Do estradiol and testosterone alter Fas-dependent apoptosis in CVB3-specific Th2 cells?
Estradiol protects Th2 cells from Fas-dependent apoptosis by increasing Bcl 2 expression, whereas testosterone promotes apoptosis, providing a potential mechanism for the observed sex differences in susceptibility to viral myocarditis.
Huber et al. (1999) studied this question.