September 1, 2002AJP Regulatory Integrative and Comparative Physiology

Increased GABAAinhibition of the RVLM after hindlimb unloading in rats

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Population

Inactin-anesthetized rats subjected to hindlimb unloading (HU) and control rats

Comparison

Bilateral microinjection of the GABA… vs Control rats (not subjected to hindlimb unloading)

Design

Preclinical

Authors

JMJulia A. MoffittStephens College CHCheryl M. HeeschUniversity of Missouri EHEileen M. HasserMissouri College

Discussion

Member takes

Implication

May explain orthostatic intolerance after deconditioning; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Inactin-anesthetized rats subjected to hindlimb unloading (HU) and control rats

Intervention

Bilateral microinjection of the GABA(A) antagonist (-)-bicuculline methiodide (BIC) into the rostral ventrolateral medulla (RVLM) before and during caudal ventrolateral medulla (CVLM) inhibition

Comparator

Control rats (not subjected to hindlimb unloading)

Outcome

Changes in mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA)surrogate

Cardiovascular deconditioning from hindlimb unloading in rats is associated with augmented GABA(A) receptor-mediated inhibition of RVLM neurons, contributing to attenuated sympathetic responses to hypotension.

Cite This Study

Moffitt et al. (2002) studied this question.

synapsesocial.com/papers/6a77428f2e130d02afec781d https://doi.org/10.1152/ajpregu.00341.2001

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Increased GABAAinhibition of the RVLM after hindlimb unloading in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased GABAAinhibition of the RVLM after hindlimb unloading in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider