Why the study?
The links between HCN genes and native I(f) are largely inferential, and it remains unknown whether I(f) is essential for cardiac pacing.
Population
Chinese hamster ovary cells and neonatal rat ventricular cardiomyocytes
Comparison
Dominant-negative HCN2-AYA vs wild-type HCN2 and HCN4 vs control
Design
Preclinical study using adenoviral gene transfer
Authors
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No immediate clinical implications; leaves open HCN channels as targets in human pacemaker biology.
HCN channels are the major molecular component of native I(f) and are essential for the spontaneous beating of neonatal cardiomyocytes.
Er et al. (2003) studied this question.
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