Why the study?
Does antimicrobial prophylaxis prevent primary wound infections in neurosurgical patients?
Does antimicrobial prophylaxis prevent primary wound infections in neurosurgical patients?
Antimicrobial prophylaxis in neurosurgery was associated with an absence of primary wound infections in a large case series.
Suggests possible benefit of prophylaxis in neurosurgery; leaves open need for randomized trials to confirm efficacy.
A program of antimicrobial prophylaxis for neurosurgical patients was implemented at three community hospitals after review of the previously recorded cases of postoperative sepsis and the antibiotic sensitivity of the prevailing pathogen, Staphylococcus. No primary wound infections occurred in a series of 1000 consecutive operations. The rational basis for prophylactic antibiotics is discussed.
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Savitz et al. (1981) studied this question.
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