What question did this study set out to answer?

This study aims to examine the sex-specific benefits and risks of antihypertensive treatment for stage 1 diastolic hypertension.

February 26, 1996Archives of Internal Medicine

Efficacy and Tolerance of Antihypertensive Treatment in Men and Women With Stage 1 Diastolic Hypertension

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Why the study?

Does active antihypertensive drug therapy reduce combined clinical events and improve blood pressure in men and women with stage 1 diastolic hypertension compared to lifestyle intervention alone?

Population

902 African-American and white hypertensive adults, age 45 to 69 years, with stage 1 diastolic hypertension.

Comparison

Active antihypertensive drug therapy combined… vs Placebo combined with nutritional-hygienic…

Design

RCT, Randomized

Follow-up

4 years

Authors

CLCora E. LewisUniversity of Alabama at Birmingham

Discussion

Member takes

Implication

Supports similar antihypertensive effects in women and men; confirms consistency across sex in stage 1 diastolic hypertension.

Key Points

This study aims to examine the sex-specific benefits and risks of antihypertensive treatment for stage 1 diastolic hypertension.
Participants included 557 men and 345 women aged 45-69 with stage 1 diastolic hypertension.
Randomized assignment to treatment with medications or placebo for 4 years.
Nutritional-hygienic intervention was provided alongside treatments.
Women on placebo were less likely to receive step 1 therapy alone compared to men (46% vs 66%, P < .01).
Greater reductions in mean systolic blood pressure were observed in both sexes with active treatments compared to placebo.
Quality-of-life improvements were noted in both men and women receiving active drugs.

Structured PICO

Does active antihypertensive drug therapy reduce combined clinical events and improve blood pressure in men and women with stage 1 diastolic hypertension compared to lifestyle intervention alone?

Population

902 African-American and white hypertensive adults (557 men, 345 women), age 45 to 69 years, with stage 1 diastolic hypertension (diastolic blood pressure <100 mm Hg).

Intervention

Active antihypertensive drug therapy (chlorthalidone 15 mg/d, acebutolol 400 mg/d, doxazosin 2 mg/d, amlodipine 5 mg/d, or enalapril 5 mg/d) combined with nutritional-hygienic intervention.

Comparator

Placebo combined with nutritional-hygienic intervention.

Outcome

Combined clinical eventscomposite

Active antihypertensive treatment provides similar blood pressure reductions and trends toward reduced clinical events in both men and women with stage 1 diastolic hypertension compared to lifestyle intervention alone.

Limitations

Exploratory analyses

Cite This Study

Cora E. Lewis (1996) studied this question.

synapsesocial.com/papers/6a77500f576efb0ddaf73fc5 https://doi.org/10.1001/archinte.1996.00440040047006

Topics

Hypertension management

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Efficacy and Tolerance of Antihypertensive Treatment in Men and Women With Stage 1 Diastolic Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Efficacy and Tolerance of Antihypertensive Treatment in Men and Women With Stage 1 Diastolic Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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Topics

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