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September 1, 1993AJP Regulatory Integrative and Comparative Physiology

Cardiovascular consequences of microinjection of vasopressin and angiotensin II in the area postrema

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Why the study?

Does microinjection of angiotensin II and vasopressin into the area postrema alter blood pressure and heart rate in anesthetized rats?

Population

Urethan-anesthetized male Sprague-Dawley rats

Design

Preclinical

Authors

VLVicki L. LowesHong Kong University of Science and TechnologyLML. E. McLeanQueen's UniversityNKNorman W. KastingUniversity of Calgary

Discussion

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Member takes

Implication

Should not inform clinical practice; leaves open area postrema contributions to human cardiovascular regulation.

Structured PICO

Does microinjection of angiotensin II and vasopressin into the area postrema alter blood pressure and heart rate in anesthetized rats?

P
Population
Urethan-anesthetized male Sprague-Dawley rats
I
Intervention
Microinjection of angiotensin II (ANG II) (10 pg to 500 ng) or vasopressin (VP) (10 pg to 500 ng) into the area postrema, with or without systemic administration of antagonists (losartan, PD123319, V1 antagonist) or microinjection of V2 agonist (DDAVP)
O
Outcome
Mean arterial blood pressure and heart ratesurrogate

Angiotensin II and vasopressin act centrally at the area postrema via AT1 and V1 receptors, respectively, to increase blood pressure in anesthetized rats.

Cite This Study

Lowes et al. (1993) studied this question.

synapsesocial.com/papers/6a775027576efb0ddaf73fedhttps://doi.org/10.1152/ajpregu.1993.265.3.r625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of pressor effects by angiotensin in the nucleus tractus solitarius of rats1984 · 73 citations
  2. 2Cardiovascular effect of angiotensin-(1–12) in the caudal ventrolateral medullary depressor area of the rat2013 · 6 citations
  3. 3Angiotensin II-Induced Hypertension: Effects on Central and Peripheral Atrial Natriuretic Peptide.1995 · 8 citations
  4. 4Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats2002 · 92 citations
  5. 5Systemic site of action for pressor effect of angiotensin II injected into the fourth cerebral ventricle of rats?2002 · 1 citations