Key result
Depression was associated with a significantly higher risk of left ventricular hypertrophy in patients with uncomplicated hypertension (OR 2.51; 95% CI 1.14-5.52; p=0.022).
Why the study?
Hypertension and depression worsen cardiovascular outcomes, and depression may be a key factor contributing to hypertensive left ventricular hypertrophy.
Is depression associated with an increased risk of left ventricular hypertrophy in patients with uncomplicated hypertension?
Observational (n=353)
Is depression associated with an increased risk of left ventricular hypertrophy in patients with uncomplicated hypertension?
Odds Ratio: 2.51 (95% CI 1.14–5.52)
p-value: p=0.022
Depression is significantly associated with an increased risk of left ventricular hypertrophy in patients with uncomplicated hypertension, particularly in males, those under 60 years of age, and those with higher education.
Depression screening may flag higher LVH risk in hypertension; leaves open whether treatment alters progression.
Previous studies have shown that hypertension and depression are associated with worse cardiovascular outcomes and reduced quality of life. Left ventricular hypertrophy (LVH) is strongly linked to increased mortality and cardiovascular disease, and depression may be one of the key factors contributing to hypertensive LVH. The authors consecutively enrolled 353 patients with uncomplicated hypertension between November 2017 and May 2021. All participants completed the Hamilton Depression Scale (HAM-D) to assess their depression status, with depression defined as a HAM-D score of 20 or higher. Linear regression analysis revealed a positive association between HAM-D and LVMI (adjusted β, 1.51, 95% CI, 1.19-1.83, p < .001). Logistic regression models showed that individuals with hypertension and depression had a higher risk of LVH than those with hypertension alone (adjusted OR, 2.51, 95% CI, 1.14-5.52, p = .022). The association between depression and LVH significantly interacted with age, sex, education levels, but not BMI and household income. Following age, sex, and education levels stratification, an independent association of depression and LVH was observed only in age <60 years (age <60 years: OR, 7.36, 95% CI, 2.25-24.13, p < .001), male (male: OR, 16.16, 95% CI, 3.80-68.73, p < .001), and higher education levels (high school and above: OR, 11.09, 95% CI, 2.91-42.22, p < .001). Our findings suggest that depression is a significant risk factor for LVH in hypertensive patients, particularly in those who are under 60 years of age, male, and have higher education levels.
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Shi et al. (2023) conducted an observational in uncomplicated hypertension (n=353). Depression (HAM-D score ≥ 20) vs. Hypertension alone (no depression) was evaluated on Left ventricular hypertrophy (LVH) (OR 2.51, 95% CI 1.14-5.52, p=0.022). Depression was associated with a significantly higher risk of left ventricular hypertrophy in patients with uncomplicated hypertension (OR 2.51; 95% CI 1.14-5.52; p=0.022).
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