Key result
Higher baseline proximal tubular fractional reabsorption of sodium was associated with a significantly increased risk of incident hypertension over 8 years in initially normotensive men (OR 1.34).
Why the study?
Does higher proximal tubule fractional reabsorption of sodium predict incident hypertension and blood pressure increases in initially normotensive men?
Cohort (n=294)
No
Does higher proximal tubule fractional reabsorption of sodium predict incident hypertension and blood pressure increases in initially normotensive men?
Odds Ratio: 1.34 (95% CI 1.06–1.7)
p-value: p=0.02
An enhanced rate of sodium reabsorption in the proximal tubule independently predicts the risk of incident hypertension and blood pressure increases over time in initially normotensive men.
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Does not support changing hypertension risk assessment; leaves open causal role of proximal tubular sodium reabsorption in men.
D’Elia et al. (2017) conducted a cohort in Incident hypertension (n=294). Higher proximal tubular fractional reabsorption of sodium vs. Per 1 SD increase in proximal fractional sodium reabsorption was evaluated on Risk of incident hypertension (OR 1.34, 95% CI 1.06-1.70, p=0.02). Higher baseline proximal tubular fractional reabsorption of sodium was associated with a significantly increased risk of incident hypertension over 8 years in initially normotensive men (OR 1.34).
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