Why the study?
Does proximal sodium reabsorption determine blood pressure responsiveness to salt in hypertensive patients?
Population
65 subjects, comprising 38 hypertensive patients and 27 normotensive subjects (15 young and 12 age-matched)
Comparison
High and low sodium diet vs Normotensive subjects on the same diets
Design
Cohort
Authors
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Supports proximal reabsorption as a determinant of salt-induced BP response in hypertension; hypothesis-generating from observational data and requires prospective confirmation.
Does proximal sodium reabsorption determine blood pressure responsiveness to salt in hypertensive patients?
Proximal sodium reabsorption appears to be an independent determinant of blood pressure response to salt in patients with hypertension.
Chioléro et al. (2000) studied this question.
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